The internet has proven to be very clever with its "loss" memes. I keep seeing innovative and/or fun applications of it before I ever feel they're getting stale.
I do not care what the creator of The Game says, he lost ownership of it years ago, society decides when it's over and it's not, so you just lost the game...
There's a comic, titled "Loss", which is infamous, because it's incredibly fucking depressive. People don't enjoy being reminded of it. And so, of course, it has become an internet culture / meme thing to do precisely that, but in a sneaky way.
In particular, the comic has 4 panels and an arrangement of characters in a certain, recognizable pattern. So, over time, it's been reduced ad absurdum to just this pattern.
Well, and in the meme above, it becomes apparent that it's replicating the Loss pattern, when that fourth panel has the DNA flipped on its side. So, the joke is that we have the pattern-seeking brain for recognizing Loss.
If I recall correctly, it's not infamous for being super depressing but because it used to be a light hearted web comic (CTRL+ALT+DEL) about nerds doing nerd stuff and then the author decided to go into this weird dramatic arch of an ongoing love story that just didn't really fit into the whole thing. The "Loss" strip was the overly dramatic peak of this arch and I think at this point people were already making fun of it. While the topic certainly is pretty depressing, it was more the fact that this whole thing was rather cringeworthy and over the top that started the whole meme.
I think a good way to introduce people to the loss format is to show them the original vs the two-stick version, and then show the derivatives. It's golden and still makes me laugh!
I really like this one, because there's two jokes in it. One is that our pattern seeking brain allowed us to study evolution, our genome, etc. And the other is the Loss pattern meme, which I didn't even notice at first.
While pattern-seeking will indeed help you to avoid predators (and connect imagery to extremely over-memed webcomics), it's also useful for so much more!