Years ago I tried modding Fallout New Vegas and I think 4 on Fedora ages (I was running Fedora 28 at the time) ago using Mod Organizer 2 and it wouldn't work for reasons I didn't understand, possibly file system related. I'm thinking of switching to Pop! OS full time but I'd still like to play either modded Skyrim or FO4 from time to time, preferably using MO2.
it seems like it does but I didn't tested, there is a part of the install script that adds a handler for nexus links but I opted to not install that part.
I use vortex, it was dead simple to set up if you read the instructions (like disabling internet access and disabling update checking) and it has worked flawlessly for 1.5 years
I've never used MO2, but with Vortex its a pain in the dick. Gotta manually download the games yourself, individually, then drag them into vortex to install them, or just dump them in the game directory appropriately if you don't care about being able to reverse it without a reinstall.