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Psilocybin-assisted therapy for major depression increases psychological flexibility

www.nature.com Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial - Scientific Reports

Several phase II studies have demonstrated that psilocybin-assisted therapy shows therapeutic potential across a spectrum of neuropsychiatric conditions, including major depressive disorder (MDD). However, the mechanisms underlying its often persisting beneficial effects remain unclear. Observationa...

Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial - Scientific Reports

Psychological flexibility is a multifaceted construct composed of:

(1) openness to experience (experiential acceptance);

(2) behavioral awareness (i.e., mindful attention to the present moment); and

(3) values-driven action

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