ANCA vasculitis and IgA nephropathy linked to silica exposure
ANCA vasculitis and IgA nephropathy linked to silica exposure
Summary. There is a recognized association between silica exposure and Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV); however, n
Key learning points
What is already known about this subject
Silica is known to be immunogenic and is associated with autoimmune diseases.
There is a known association between ANCA-associated vasculitis and silica exposure, although the exact mechanism of injury is not known.
There are only a few case reports describing the association of silica exposure and IgA nephropathy.
What this study adds
This is the first documented case report, to our knowledge, of co-existing ANCA-associated vasculitis and IgA nephropathy linked to hilar lymphadenopathy due to silica exposure.
This case highlights the relevance of occupation exposures in renal disease, and the immune-stimulatory effect of silica.