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ANCA vasculitis and IgA nephropathy linked to silica exposure

academic.oup.com ANCA vasculitis and IgA nephropathy linked to silica exposure

Summary. There is a recognized association between silica exposure and Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV); however, no cle

ANCA vasculitis and IgA nephropathy linked to silica exposure

Key learning points

What is already known about this subject

Silica is known to be immunogenic and is associated with autoimmune diseases.

There is a known association between ANCA-associated vasculitis and silica exposure, although the exact mechanism of injury is not known.

There are only a few case reports describing the association of silica exposure and IgA nephropathy.

What this study adds

This is the first documented case report, to our knowledge, of co-existing ANCA-associated vasculitis and IgA nephropathy linked to hilar lymphadenopathy due to silica exposure.

This case highlights the relevance of occupation exposures in renal disease, and the immune-stimulatory effect of silica.

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