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How viable is it to use VanillaJS in 2024?

I'm a full-stack developer, looking for an internship at the moment. I feel like I'm really tired of React and Svelte. I am so done with how there's a lot of moving parts and complexity introduced by various tools, like ESLint, Prettier, TypeScript, and Tailwind. Can I work on a back-end application of my choice, while also having the freedom to not use a JavaScript runtime, in a professional environment? Can I also do modern JS stuff like tree-shaking, minification and code-splitting? How viable would be it to do so? And would it be easier to maintain?

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