Do you use it? Do you like it? Dislike it? How do you think it compares to the native package manager, or other cross-distro package managers like Snap or Flatpak?
With access to the AUR on Arch-based distros, I don't have the need for it. Normally, I choose:
Distribution package
Flatpak
AUR
AppImage
I haven't yet come across something which is available in homebrew but not in one of these options. I'd use it if I had a need. Currently, I haven't needed to use any AppImages but have in the past when Flatpak has been slower to update for Ultimaker Cura.