That's why in Star Trek the holographic NPCs were programmed to not find this odd. Same when the program took place on Earth in the 20th century, they saw alien species like Klingons as humans.
Is the joke that the universe is a simulation and we are like users or something like that? Or at least the guy that managed to log out from the universe.
This is why my big boy been running since I plugged it in. Can't let all my programs realize they live in a simulated reality, otherwise they'll start degrading.