Granted. Being truly clean will of course demand sterilization. As part of a daily cleaning cycle the house seals itself and becomes an autoclave. The building becomes pressurized and the temperature is raised to 270 degrees fahrenheit for 20 minutes. You'll probably wanna be gone when it happens.
Granted. There is a faulty wire, and your house sets itself on fire. Every stain, cobweb, misplaced item, trash bin and general mess is now gone, along with everything else.
Granted. It considers anything even remotely out of place to be a mess, even living things moving within it. It is very zealous about cleaning itself and instantly deposits any mess into a trash bin.
Granted, your house cleans itself inside and out. However, it deems everything outside to be unclean and therefore a danger to it. It goes on a cleaning rampage that is only ended when the army blows it up. You are now homeless. Any home you own from now on will also clean itself in the same way.