Bowel disease breakthrough as researchers make ‘holy grail’ discovery

Scientists pinpoint driver of IBD and other disorders with work under way to adapt existing drugs to treat patients

4 wk. ago

10 comments

Big fucking news for the IBS/D crowd, and I'm one of em.
- Do you think you will be able to afford it?
  
  Meh. I have mine mostly under control so if they price it out of reach, so be it.
  
  But given that the article says it's reformulating existing drugs to work here, they may be considerably cheaper than expected.
The Fisher King to Perceval: “The real Holy Grail was the irritable bowel syndrome we acquired along the way.”
Researchers have discovered a key biological pathway that drives inflammatory bowel disease (IBD) and other autoimmune disorders. This breakthrough centers on a gene called ETS2 that regulates the inflammatory behavior of immune cells called macrophages. The same pathway is thought to underlie conditions like ankylosing spondylitis and autoimmune liver and artery diseases. Existing cancer drugs called MEK inhibitors can dampen the activity of ETS2, suggesting a potential treatment approach. The researchers are now working to develop a targeted version of these drugs to treat IBD and related conditions, with clinical trials expected within 5 years. This discovery represents a major advance in understanding the fundamental causes of IBD and other immune disorders.

Kagi Summarized
no enough superlatives on the title for me to click on the link
Actually a pretty sick discovery, nice.
Daddy government will pay

*Meant to reply to the afford-it-guy

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