You can make one change to the world/reality that makes people's lives more inconvenient or awkward. What do you change?

I quite like the (I think?) Jewish curse: "may your laundry never dry". That would suck wearing clothes that are always slightly damp.

Every set of stairs has one step that is slightly taller than the rest

You know how you sometimes get a pebble stuck under your shoe and walking just feels weird until you remove it?

That, but there’s no actual pebble.

Everytime you open a door it moans with pleasure.

You lose the ability to differentiate between a fart and a poo.

Bell ringing sound every time you get an erection

No matter how hard one squeezes, there’s ALWAYS three or four drops of pee leftover, poised to strike after one finishes their business.

Make it so that when you arrive home you're never allowed to put your keys in the same place more than once.

Forgot something in the car and have to go back out? Time to find a new spot...

wind makes everyone ticklish

Eyelids become translucent. In other words, you can still see anything and everything when your eyes are closed.

All doors you try to open actually open the opposite direction

You must greet everyone you meet with a handshake and ten seconds of uninterrupted eye contact. Forced smiles and a serious talk about how you really are doing are also mandatory.
Pretty awkward if you ask me :)

USB-C now has the same connector directionality problem that USB-A does

switch locations of penis and anus

Everyone is ever so slightly telepathic, functionally making a web of felt emotions with no thoughts connecting them so what you feel from this is basically a summary of the people in the area around you.

Example: Everyone could be focused at work, nothing major going on, until someone thinks about their significant other and all of a sudden there's a tiny bit of horny thrown in the mix, everyone knows its there, and no one knows who put it there.

Mirror every object. You don't realize how many things are designed with a right-handed assumption unless you aren't right handed. Also, most people can't read well anymore because it's all backwards

Any time you use something powered by a fossil fuel your pinkies ache about as much as a lightly stubbed toe.

Remove the ability to remember if you turned something off.

You never hear someone the first couple times they try to pay you a compliment

Sneezing is excessively messy.

From now on, you get static shocked every time you touch anything.

Telepathy for everyone. Instant chaos.

Everyone's butt hole could be anywhere on their body. Everyone needs a different kind of toilet to properly position themselves. Everyone starts aligning themselves as friends based on the location of their butt hole. "Oh sorry I can't stay too long. My butthole is in my armpit."

It always takes three rotations to plug in a USB cable.

Friction stops working.

Both of these are my moms ideas.

First your cars never start.

Or the other option

We no longer have cell phones, we have to go back to land lines.

One of your socks is always wet

I'd make every scissor a little bit loose so whatever it's cutting turns sideways and gets stuck near the end.

It's impossible to determine the charge level of phone batteries. It's now up to you to keep track or your activities and estimate when you'll need to charge, otherwise it will just turn off on its own when the battery runs out.

Whenever you say anything to anyone the other person always knows exactly what your thinking is behind what you are saying.

That would make it nearly impossible to lie, cheat or deceive others, even for the smallest thing.

So that way when your girlfriend asks you if you would still love her if she were a worm, even though you would say, "Of course my love!" She would know you actually mean "what the fuck are you talking about?" And you would know she actually meant "my emotional batteries are running dry and I want you to recharge them"

Men die after they fertilize women just like mantises

Any time you try to get tape off a roll, it rips halfway through and turns into a mess. The same with toilet paper

everytime you are going to sit, you have to declare it out loud

No matter how much you wipe there is still poop

Hot beverages are always either too hot or too cold.

Brain now naturally resists sleep for as long as possible, so everyone stays awake for two or three days before crashing uncontrollably.

At random times whenever you are traveling in any vehicle, you simultaneously feel a sneeze coming on, and yet have to pee a little bit too. However, you can neither sneeze nor pee until you are out of the vehicle.

Inconvenient on a bus/train or as a passenger, deadly if you're driving. Bicycles are right out, I suppose.

Make flashlights scream when you turn them on.

Have every squeeze of tooth paste contain an air bubble that spews a bit on you.

Have a single dead pixel in the center of every display.

Make fridge doors not close automatically.

Make cars moan, whether ICE or electric.

There’s always just a little bit left while wiping. You can never get it completely clean.

This'd likely a bit more than inconvenience, but honestly, to the degree that it would be more than that (or more accurately to the people to whom it would be more than that), I just don't give a shit.

Make it literally impossible to knowingly lie. Full stop.

All mouthwash turns to orange juice after brushing your teeth

Thumb and ring finger change places. Opposable ring fingers.

Everyone has to skip instead of walking.

I would give everyone noclip mode.

Convenient because you can fly anywhere and through walls. People's commutes would be so much shorter! You could visit any country you wanted without even needing planes. Everyone would experience an unprecedented level of freedom.

Inconvenient because of the messy implications of getting stuck in walls if you turned it off at the wrong time. Also people would probably just be able to take anything they wanted without repurcussions so the world might devolve into chaos. You wouldn't really be able to jail anyone. Security and privacy would be hard to come by.

Sex is painful for the man too

change the date system to day month year

I wish for water to no longer be a bipolar molecule

Clothing sleeves, pant (trouser) legs, underwear garments, socks, etc. all have one side slightly longer than the other

Make everyone listen to 10 hours of cow sounds on repeat.

Every time you drink anything or are near running wather youl get splashed in the groin and would look like you peed yourself.

Everyone has a (changing) tattoo on their forehead telling how many deaths are caused by their overconsumption of the planet's resources.

All environmental externalities are included in all prices. Also currency is manipulated to prevent overconsuming the planet's resources

Whether or not there is an object acting upon them, earbuds sporadically jerk out of your ears every few minutes.

You are physically unable to litter.

Everyone who eats at fast food restaurants gets diarrhea for 3 days

Is there really not a single answer saying "I would rather not make everybody's lives more inconvenient just because I could"?