Apps won't launch from GUI?

I've noticed that some apps sometimes don't start from the GUI. I've seen it on several computers (all running Ubuntu 22.04). That includes double-clicking an appimage icon from an explorer window, or launching an app through a launcher shortcut. But if I open them manually from a terminal window they never fail to start.

The terminal workaround is fine... But any ideas what could be wrong with the GUI? Is there a service I can restart to try to get the functionality back?

EDIT: I'll add that the issue is sporadic. Steam will open fine from the GUI today, but tomorrow it won't, etc. (It's not as simple as a bad path in a shortcut)