Bottles (https://usebottles.com/) is what you're looking for, sandboxing is one of it's primary features. It can use lutris prefixes too if you need them.
EDIT: It's only sandboxed if you use the flatpak, just FYI.
Probably? Honestly I just read the sections of the docs that were relevant to what I needed and clicked buttons until things worked. Tutorials are dangerous because the moment they are published they are out of date, unless the author goes back and updates it regularly which is pretty rare, or impossible if it's something like a youtube video.
Anyway it's a GUI application with lots of tool tips and all that, it's not difficult to use.