This COVID study has been tracking immunity for 3 years. Now it's running out of money

A long-running study into COVID-19 immunity has unearthed promising insights on the still-mysterious disease, one of its lead researchers says — but she's concerned its funding could soon dry up.

The Stop the Spread project, a collaboration by the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa, has been monitoring antibody responses to COVID-19 in hundreds of people since October 2020.

While there are other longitudinal COVID-19 studies underway, Stop the Spread is notable because it launched so early in the pandemic that some participants hadn't even fallen ill yet, said Dr. Angela Crawley, a cellular immunologist with OHRI and one of the project's co-investigators.

That gave them access to cells and plasma untouched by the COVID-19 virus — a unique baseline, Crawley said, from which they've since tracked changes in immune responses and antibody levels.

For instance, Crawley said they've uncovered "pretty compelling" evidence of a link between one's biological sex and one's ability to generate and maintain antibodies.

Across all age categories, the data seems to suggest women are slower to shed antibodies than men, Crawley said. The distinction is sharpest in younger age groups, with rates of antibody loss gradually converging the older people get.