I remember when a biologist asked us for help - Excel crashed on processing his 700MB tables. Took some time and Chatgpt to convince him to do the analysis in R. It worked out in the end and he is now recommending this solution to his colleagues, which is nice.
I’d be embarrassed to call myself a scientist if I didn’t know how to at least script basic shit and effortlessly reproduce data analyses. The bar for entry into every single stage of academic science is too fucking low. 95% of this literature is irreproducible shit, in part because fuckwits don’t know how to code. Scientists don’t need to be software engineers, but yes, they need to be able to program. It wasn’t this way 20 years ago, but it most certainly is nowadays.
Excel sucks open ass. At storing data, at displaying data, at analyzing data. Scientists, of all people, should understand how to use an RDBMS and a data processing framework like R.
Programming in R or Python isn't a lot harder than learning how to get Excel to do what you want. I'd wager it's easier since you don't have to fight your tools.
Excel has its place for simple quick calculations. But at some point it's simply the wrong tool.