What unusual genre mixing video games would you recommend to try?

Cult of the lamb

Neon white

Crypt of the necrodancer

Golf story

Tower tactics liberation is a neat combination of tower defense and deck builder.

Dave the Diver. Undersea adventure quests and restaurant management sim.

Sanctum 2 is a really well done tower defense that's also a first person shooter. I always thought it was underrated.

NieR Automata
Child of Light
Tetris - The Text Adventure

Are you asking for game recommendations or a jam prompt?

I'm guessing recommendations not prompts.
- Especially since the title says ".. video games totry"
I'm asking for game suggestions.
The video game market fascinates me. Every quarter of a year, there are what feels like hundreds of video games that come out. It's baffling and frustrating the amount of video games that come out but tend to party make a 'splash' in the video game industry market. Especially those who take creative risks and don't get much coverage. Hence why I asked the question. =)

I'll caveat this with I think a lot of games mix genres so you might even want to narrow it down a bit. (For example Ghost Recon: Wildlands is a coop, open world, action, adventure, stealth, and a modern military third person shooter.)

But I'll try and give some more noticablely mixed ones:

Doki Doki Literature Club (Don't look anything up just play it, don't worry if it doesn't seem like something you'd usually enjoy)
Natural Selection 2 (Space Marines vs aliens pvp fps with commanders playing a rts match)
Superhot (A fps with evading bullets offering a puzzle-like element)

I love Natural Selection 2! Really glad that an FPS-RTS game has been able to make it and stay around. I still hold out hope for another FPS-RTS game to make it big. There have been a couple/several that have made it to market but most of them are not finished or died in early access development sadly.
- One other game that I think a lot of people overlooked as being one was Battlefield 4 + Hardline. Which had their own commander modes. Last I checked 4 still had community servers running, might even have more players that NS2 still.