Nice to see a significant upgrade on computing and GPU power.
What irks me is that it still does not have a native M.2 or similar slot. And that you need a HAT for either running it with an M.2 or POE.
Another issue is the PSU. It has 27W, which means about 5A at 5V. How much does the RPi and the core parts (fan, M.2 hat+stick) use, and how much will be left to "feed" the USB3 ports?
Edit: Just another thing I just saw: They offer 4 and 8GB models at the start, and I though: Well, maybe they will do bigger models later. Does not look like it, though: It has four config resistors labeled 1, 2, 4, and 8GB.