I always suspected my antidepressants were messing with my ability to party.
I always suspected my antidepressants were messing with my ability to party.
pure.johnshopkins.edu
Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use
this has been known among users of these drugs for quite a while now. They bond to the same receptors, so they interfere with each other. You can mitigate this a bit by going 24 hours without your SSRI/SNRI (ie skipping the dose that would precede the trip), and increasing dose of the psilocybin by ~1.5x. Or so I hear
Also pretty dangerous to do MDMA without pausing your SSRIs and just about deadly to do them when on MAOIs
true, but MDMA is a different drug