I would say Hinterland, but that game can be got for a couple bucks and really doesn't overstay its welcome if you wanted to just do a single run. Seriously, I love that game enough that I considered modding it, but there's just enough layers of encryption that it isn't worth bothering with for a low-tech guy like myself.
A few things I've considered is items to alter production values and introduce certain class upgrades to some of the people in town. Meanwhile a couple items might get removed for redundancy, like the items for trappers and hunters. There's a couple items that only work with the lower stage trappers and due to randomness can sometimes only spawn after you've upgraded your trappers to hunters. Other options include variations on hunters and maybe further upgrades for the inn.