Researchers have published a method of rescuing cells from damaged mitochondria and cellular senescence, potentially alleviating major aspects of aging. Bad mitochondria must be […]

An analysis of oral microbes in older adults has indicated an association between microbial diversity and executive function performance [1]. Multiple factors impact cognitive impairment risk Aging is one of the major risk factors for cognitive impairment and dementia, but […]

Recent epigenome-wide studies have identified a large number of genomic regions that consistently exhibit changes in their methylation status with aging across diverse populations, but the functional consequences of these changes are largely unknown. On the other hand, transcriptomic changes are mor...

In the newest study by the Interventions Testing Program, 16α-hydroxyestriol and canagliflozin significantly increased lifespan in male mice but were deleterious for females [1]. The golden standard The Interventions Testing Program, now entering its 20th year, is a monumental […]

New research shows that people who develop dementia often begin falling behind on bills years earlier.

The pursuit of a cure for Alzheimer's disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies.

Background People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and translocation, which may lead to non-AIDS-related aging-associate...

Disease outbreaks and human conflicts help dictate regional differences in longevity.

Wang et al. profile age-dependent miRNAomic changes in worm tissues and extracellular vesicles (EVs). They show that ageing controls miRNAs in a tissue-specific manner and their findings further suggest a complex EV-mediated miRNA trafficking network across tissues.

Scientists have found a way to reprogram T cells to fight aging. After using them to eliminate specific cells in mice, the scientists discovered they lived healthier lives and didn't develop aging-associated conditions like obesity and diabetes. Just one dose provided young mice with lifelong benefi...

Doctors are exploring how to use animal organs but keep them outside people's bodies.

In a meta-analysis of 5,000 participants, including more than 500 who underwent in-person assessments over two years, multivitamins showed benefits for memory and global cognition. Learn more.

Buffalofish have surprisingly long life spans, a new study shows—and live their best lives into their 80s and 90s. What can humans learn from them?

How cell replication ultimately results in aging and the Hayflick limit are not fully understood. Here we show that clock-like accumulation of DNA G-quadruplexes (G4s) throughout cell replication drives conserved aging mechanisms. G4 stimulates transcription-replication interactions to delay genome ...

One long-lasting result of the hype engineered over sirtuin 1 overexpression as a possible avenue to modestly slow aging is a continued focus on other sirtuins in the context of aging. Sirtuin 1 overexpression turned out to be entirely unimpressive, a dead end. Sirtuin 6, however, is more interestin...

The association between a plant-based diet (vegetarianism) and extended life span is increasingly criticised since it may be based on the lack of representative data and insufficient removal of confounders such as lifestyles.We examined the association ...

Life isn’t just about how long we live; it’s about how well we live it. We often hear about increasing our lifespan, but is a longer life worth it if we can’t move and become dependent on others? What’s equally, or even more important, is enhancing our healthspan—the period during which we enjoy a g...

Our mammal ancestors evolved to compete with dinosaurs but may have lost something in the process.

In the fifth decade of life, our brain begins a radical "rewiring" that results in networks becoming more integrated and connected.

In this study, the authors introduce the concept of a unique cellular subtype within the organic stroma, which does not conform to a typical young or senescent but is significantly associated with age-related organic dysfunction among the elderly.

Selective vascular access to the brain is desirable in metabolic tracer, pharmacological and other studies aimed to characterize neural properties in isolation from somatic influences from chest, abdomen or limbs. However, current methods for artificial control of cerebral circulation can abolish pu...

Neuroscientists at the Faculty of Medicine and Surgery of the Catholic University, Rome, and the Fondazione Policlinico Universitario Agostino Gemelli IRCCS have genetically modified a molecule, the protein LIMK1, which is normally active in the brain, with a key role in memory. They added a "molecu...

Dr. Kristin Kostick discusses what might happen to our sense of time if we live radically longer lives.

This nationwide cohort study conducted in Sweden compares the temporal risk patterns of psychiatric disorders before, at the time of, and after a dementia diagnosis between patients without vs with dementia.

Some people in their 80s and 90s show shockingly little decline in their brainpower. Scientists are beginning to understand what makes them different and how the rest of us might benefit

There’s a growing need to slow down the aging process. The world’s population is getting older and, according to one estimate, 80 million Americans will be 65 or older by 2040. As we age, the risk of many chronic diseases goes up, from cancer to heart disease to Alzheimer’s. BioAge Labs, a company b...

Human cells with impaired mitochondria expend more energy. While this hypermetabolism enhances a cell's short-term survival, it also dramatically increases the rate at which the cell ages.

A small number of low-cost and generic drugs have extensive human use and safety data, but also a sizable, compelling body of animal study evidence to either (a) suggest a likely modest slowing of aging, e.g. rapamycin, or (b) demonstrate the ability to target a mechanism of aging to reverse age-rel...

Background Components of social connection are associated with mortality, but research examining their independent and combined effects in the same dataset is lacking. This study aimed to examine the independent and combined associations between functional and structural components of social connect...

Guo et al. demonstrate that oral administration of chiral nanoparticles ameliorates Alzheimer’s disease-associated pathology and cognitive decline in mice via an increase in the gut metabolite, indole-3-acetic acid, potentially a therapeutic target.

Some people infected with the common, cat-borne parasite Toxoplasma gondii are more likely to be frail as they get older, new research shows.

Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly accurate molecular biomarker of a...

Why we should all try to be biologically younger.

To assess the coming challenges of caring for large numbers of frail elderly as the Baby Boom generation ages.A review of economic and demographic data as well as simulations of projected socioeconomic and demographic patterns in the year 2030 form the ...

Tests in US will see canines given tablet disguised as a sweet treat that scientists claim may expand lifespan with less disease risk

Klotho is a longevity-associated protein. More of it extends life span in mice, and higher levels correlate with human health in later life. Klotho improves kidney function in older individuals, and improves cognitive function at any age, but it is far from clear as to which of the many aspects of c...