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If you had to give one piece of advice that is pretty much universally applicable, what would it be?

I wouldn't dare defile Douglas Adam's memory by not mentioning that you should keep a towel with you at all times, but my second contender is a surprisingly short three-parter:

  1. never lie.
  2. never tell the whole truth.
  3. never pass up a chance to use a real bathroom.
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