I don't know, a lot of the red is over pretty rural areas in the south and parts of the southwest, and the majority of the most rural parts of the country are "not significant".
Also that big blue part in the middle covers some very large cities.
The 'not significant' part could be due to low numbers in general, so they can't get the variances small enough to get low p numbers. It's a quote that I can't quite remember perfectly that is well known in sociology/psychology: "The only reason our findings aren't significant is because we're too damn lazy to drag enough people in for the study."
Absolutely not. There's some hugely populated places in cold spots here and very rural hot spots. Rural Georgia is all red here. The greater San Francisco bay area is a cold spot. Dallas-Ft. Worth, Minneapolis, Seattle too. Some very rural parts of Mississippi are hot spots here.