Harris is missing 10 million votes that Biden got in 2020. It looks like many of those 10 million were suburban men who didn't vote Trump, just sat on the couch. misogyny is a viable explanation for this because otherwise you'll have to explain why Biden set the left on fire, or why Biden was so inspirational to men.
Some of it is 100% misogyny, I think some of it is also that 4 years ago the country was literally on fire in a lot of places and Trump was obviously to blame for a lot of it, so it didn't matter so much to apathetic voters if Biden's messaging was weak. Kamala may have won then too, though misogyny would have made it closer. Now the country is much more stable but still not great, but Democrats are in charge and therefore obviously to blame, so people who largely haven't been affected negatively by the Republicans (e.g. men, especially non-desperately-poor white men), are apathetic again