Depends on the isotope, of course. There are different ways it can hurt you.
If you put together a critical mass of ²³⁵U, it undergoes fission and you die in seconds without needing to ingest it.
Naturally ocurring uranium (²³³U-²³⁸U, mostly ²³⁸U) has a half-life of billions of years, so it's very weakly radioactive. It would take a lot of it to harm you from decay radiation. Or very little if you pick a very unstable synthetic isotope outside the 233-238 range (but every element "has" such radioactive isotopes, though not in nature).
Uranium is chemically toxic, which is whal will kill you if you ingest a small amount of a common isotope.
If you've got more than 52 kg of uranium 235 on your hands, I would be alarmed to learn you didn't understand how criticality worked. Although now that I think of it, there's probably an awful lot of people who indirectly handle that much when they move around a nuclear warhead and most of them probably only had a single lecture on the concept.
The thing that always blows my mind is just how freaking dense uranium is. A sphere weighing 52 kg is only 17 cm across.
I think they are referring to Uranium with natural isotopic abundance. Which is complete bullshit when you put a picture of a nuclear power plant behind it – which in most cases can not function with the natural isotopic abundance (heavy water reactors being the exception, not the rule).