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His father's murder, at the hands of his uncle and mom.
He killed his uncle and mom, and his sister committed suicide. You can argue that Ophelia was driven to suicide, but that's not entirely on Hamlet. He might have saved her if he wasn't so consumed with vengeance, but that's not how the story goes.
Or did Hamlet just think his uncle and mom killed his dad because he was a crazy guy who talked to "ghosts."
It can legitimately be argued either way, which I think is fun. Obviously the play is from the point of view of Hamlet, so we're expected to roll with the assumption that he's really really speaking with ghosts. But it could just as easily be stress induced delusions.
Never thought of it that way and that's fun