What is Something Scientific that you just don't believe in at all?
What is Something Scientific that you just don't believe in at all?
EDIT: Let's cool it with the downvotes, dudes. We're not out to cut funding to your black hole detection chamber or revoke the degrees of chiropractors just because a couple of us don't believe in it, okay? Chill out, participate with the prompt and continue with having a nice day. I'm sure almost everybody has something to add.
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I may not be answering this right, but the classification of autoimmune diseases—it’s likely a lot more complex than rheumatology would have you think.
Take Lupus for example. Yes, there are bio markers that tend to be positive in cases of Lupus. However, there are varying degrees of positivity and a massive realm of variant symptoms. Prior to use of molecular assays in medicine we grouped these “somewhat similar” presentations into a single disease entity (lupus), but in reality it likely represents a cluster of similar diseases that are slightly different ways of the body attacking itself. The same is likely true to many other “vague” autoimmune diseases. It’s also true for the crossover between neurology and psychiatry. For example, based off of modern imaging we can tell that schizophrenia has an obvious organic root (massive brain structural changes), and this means it would probably be best owned by neurology like other neurodegenerative disease. Despite this, it is still owned by psychiatry and viewed by many (including some professionals) as a “chemical imbalance.” Schizophrenia is no more a dopamine excess than Parkinson’s is a dopamine lack—and we very much treat Parkinson’s as a neurodegenerative disease, not a psychiatric one. This difference is obviously due in part as much to historical classification as it is to the health equity problems surrounding schizophrenia patients.
I think many of these classifications are caused simply by doctors refusing to say "I just don't know" and patients refusing to accept that they really don't and probably never will...
Take IBS. We are supposed to believe that there is a disease with no known cause, so many possible triggers and influencers that anyone can find some that fit and wildly varying symptoms... something similar could probably be said for many other "syndromes". Of course all of those people have something else or a combination of something else but nobody wants to admit they just don't know and everyone wants a diagnosis.
Yes—IBS is a good example of something that’s likely a constellation of different disorders (aka why it’s a “Syndrome”). There’s some promising preliminary data that a lot of IBS may actually relate back to the insecticides that are used on commercial crops (hence one of the reasons why people get relief from going “gluten free”—it may have less to do with the gluten and more to do with the chemicals on the wheat itself). Stay tuned for more.
IBS is also a more generic condition with Crohns and Colitis being related conditions with identifiable physiology and treatments. The "cause" isn't known but it's similar with genetically susceptible individuals having environmental, bacterial, immune factors. Immunomodulators being frontline treatments.
Your take on this is interesting, I have Crohn's disease so I'm always trying to learn as much about it and other autoimmune diseases as I can (I have zero background in medical science, everything I know is based off my pursuit of learning more). If I understand what you're saying correctly, rather than say Lupus from your example just being "Lupus", it should be more like diabetes where there is "Type 1" diabetes, "Type 2", etc?
For myself, I know that my condition has a very strong physical component to it, but part of that is also influenced by psychological factors as well - when I'm more stressed, then my condition flares up even worse than it normally would for example (and is one reason I've been pushing heavily on trying to get things treated on the psychiatry side of things).
I don't suppose there's anywhere to read more up on what you're referring to?
Crohns as well and infliximab the immunomodulator has basically had me in clinical remission after surgeries. For me it doesn't seem to be psychologically related or even diet, given that I don't just eat hot spicy foods constantly, but I eat all the "bad" foods and tolerate fiber etc. The microbiome thing seems to make sense in my case, I've had one significant flare in the last decade and it definitely had that feeling of a runaway feedback loop of inflammation. Infliximab basically binds to those inflammatory proteins and cuts that loop.
That was actually the first immunomodulator I tried and it went very well for me (I was about 14 years old when I first started it)! It led me to the closest form of remission that I have ever been in. Unfortunately, due to some bad circumstances I wasn't able to take it for over a year (might've been two now that I think about it) and I'm sure you're aware but for those who don't know, generally after being off any immunomodulator for a certain amount of time, you're not allowed to take it anymore due to the chances of building up antibodies that make it ineffective (and can lead to severe allergic reactions, including anaphylaxis).
Since then I've been on pretty much most of the other ones, I'm on Stelara now and while I've been told it's preventing more damage from occurring, it can't reverse the damage that has already been done (from things like scar tissue) - even after numerous resections it's still pretty bad for me.
However, I have noticed that when my depression isn't so active, then my symptoms aren't as bad - it's not a miracle cure by any means and still doesn't bring me to that previous point of remission, it's still enough for me to find it worth pursuing.
Of course, multiple doctors have concluded that my on-and-off depression is due to having a chronic illness, and my current psychiatrist is attempting to treat it as if I had BPD (something about the way it works chemically in my brain is probably similar to that of someone with BPD). Hopefully that gets me out of the vicious cycle of my Crohn's triggering my depression, which triggers my Crohn's in a catch-22 style loop.
I do find that I certainly have some bad foods (I really miss popcorn) but there are things that affect others supposedly that don't affect me, such as soda and other carbonated drinks (oddly enough I've heard for some Crohn's patients carbonated drinks can actually help them, so maybe I'm one of those?) - until I reach remission I just continue to try to push on trying as much as I can, since numerous GIs over the years just have zero clue on how to further help me sadly.
(They did make things significantly worse for me by having me on Prednisone for multiple years at a time, but that's another long story)
Have a prednisone horror story as well, couldn't taper off without severe withdrawal and it led to me needing emergency surgery after an ulcer rupture, which led to my resections and eventual clinical remission. Did they actually test you for antibodies against infliximab or is that just a general safety precaution they're following? I was off it for a couple months because of coverage issues but they had no problem starting me on it again and following normal infusion protocols. I think I've been on it for 15 years now. My GI specialist was one of the first in the area to start with the "top-down" approach for treatment around when I had my surgeries. Etrolizumab looked promising but the Phase III failed to deliver unfortunately, was hoping for that one if I had issues with infliximab.
They did test me for antibodies and I was positive for them sadly. That's quite a horrifying story for prednisone though, ironically I've always had a difficult time with the withdrawal symptoms from it during a taper-down of it, whereas with something like most opioids I pretty much have zero problem stopping them even abruptly, aside from a headache for a few days. For me I was never told about the long-term side effects from prolonged usage of prednisone, which I'm now being forced to deal with - an example of such is that it decayed most of the calcium/enamel in my teeth so this whole year I've had numerous root canals, fillings, and tooth extractions done and its not even over with. Honestly, I'm afraid of needing dentures before I even hit 40 (and I'm in my mid twenties)... Then there's the high chance of bone density issues, which I'm sure I'll end up with (if I don't already have such issues)... and I still have yet to shed all of the extra weight that I gained from it.
Works wonders for some people on a short term basis, but I'll never choose to be on prednisone ever again, short of some very exigent circumstances... and even then, I don't want to fall into the problem of starting it and not being able to be pulled off of it without declining again really rapidly (which is what led to me staying on it for so long).
Even Crohn's has different subtypes that are suspected to explain why different Crohn's patients respond differently to the same treatments. Much like the comment about lupus. Crohn's also is much more complicated than the general public is aware.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774386/
For example, it is well established that there is a subset of people with Crohn's disease who go into remission while taking an antidepressant called bupropion and we have no idea why. No one believes this is because these people's Crohn's was caused by a psychological problem, but rather that the bupropion appears to have effects on the immune system that aren't well understood. And this appears to only work in certain people. Do those people have a different "kind" of Crohn's? Different underlying genetic response to bupropion? Those questions aren't as easy to answer as you might think.
Ah thank you! This gives me something to dig into tonight, I appreciate it.
Lots of the sub comments addressed this well, but I see no reason this couldn’t be the case with Crohn’s as well—maybe even more so than Lupus given the gut brain axis and microbiome effects. Likely there are a lot of different undiscovered pathways and molecular variants involved.
Random side comment (and this is completely anecdotal) but I’ve diagnosed more new onset Crohn’s and UC since COVID than I had in my entire career previous to COVID. It makes me think there may be a component of COVID that’s similar enough to GI mucosa to cause autoimmune effects afterwards. Just need to wait to see the studies and incidence down the line.