Absolutely one of my favorite shows. It hits all the right notes for me. I can definitely understand why it wouldn't be someone's cup of tea, but it absolutely resonated with me.
one of my friends, who loves TV like this told me he had instant migraine from Wilfred :P
also, my girlfriend really didn't wanted to start it, because it was too strange for her, but after a few episodes she has fallen in love with the series.
so fucking a pity there's no other show like this (or I don't know about it at least...)