I'm currently playing Diablo IV and I generally refuse to use the healing stations and stat-boosting shrines scattered around the map. I guess I want to save them for later in case they don't respawn or something. I also don't know what the shrines do until/unless I hit them so I don't know if they're worth triggering or not. I'm getting by without them so far, so it's okay, maybe?
The shrines respawn over time. No need to worry about consuming them. The Lillith statues are permanent stat boosts to all characters, not activating them when you encounter them is harmful.
The shrines aren't really a balance element, because they only last a minute or so, and usually make you hilariously overpowered for a little bit.